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In this study, we investigated the expression of thrombin receptor in human breast cancers. The expression of thrombin receptor (PAR-1) in 28 fresh human breast cancer tissues was investigated in vitro, using Western blotting with the specific antibodies to PAR-1. The expression of PAR-1 mRNA in breast cancer cell lines was also investigated by RT-PCR. The expression of PAR-1 mRNA was detected in all six breast cancer cell lines (MCF-7, SKBR-3, MDA-MB-231, MDA-MB-453, SK-BR-3/ADR and BT-474), but not in non-tumorigenic breast epithelial cells MCF-10A. PAR-1 protein was also detected in MCF-10A and MCF-7 cells, but not in other cell lines. The expression of PAR-1 mRNA and protein were enhanced in MCF-7 cells after thrombin treatment. Thrombin can also enhance the proliferation of MCF-7 cells. The expression of PAR-1 mRNA and protein in fresh breast cancer tissues were higher than that of non-tumor tissues. This study suggests that PAR-1 may be involved in the growth and metastasis of breast cancer cells. PAR-1 may be a novel target for future treatment of human breast cancer.Q:

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Guia Me Divierto Y Aprendo 3 Grado Pdf Download
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Guia Me Divierto Y Aprendo 3 Grado Pdf DownloadThe present invention relates to a twist lock for a computer keyboard of the type having a support member, a keycap and a tilt bar, the support member having a transverse face and a longitudinal side running through an axis of rotation and having first and second longitudinal edges extending obliquely with respect to the transverse face.
Such twist locks usually comprise a first portion having an approximately rectangular cross section, which lies between the support member and the keycap. The first portion is connected with the support member via a bridge that, in the case of an angled rotation of the twist lock, has the effect that the rotation of the twist lock through a predetermined angle is made possible. Furthermore, a second portion is provided, the cross section of which is also approximately rectangular. This second portion extends between the longitudinal side of the support member and the keycap and is usually connected with the keycap via a mounting, which, in the case of a angled rotation of the twist lock, has the effect that the rotation of the twist lock through a predetermined angle is made possible.

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